A simulation of parahippocampal and hippocampal structures guiding spatial navigation of a virtual rat in a virtual environment: A functional framework for theta theory

Hasselmo et al. 2 INTRODUCTION Behavioral data indicates a role for parahippocampal regions in memory guided behavior in both spatial navigation tasks (Hagan et al., 1992) and matching tasks (Otto and Eichenbaum, 1992; Tang et al., 1997). Physiological data shows the patterns of activity in parahippocampal regions during performance of these tasks (Young et al., 1997; Suzuki et al., 1997; Frank et al., 2000) and also illustrates the cellular physiological properties which could be important for memory function (Klink and Alonso, 1997; Fransen et al., 2001).